Transformative Therapy:
Pre-Treatment Checklist
* Use this planning guide to stay organized before the treatment process starts
Preparing for transformative therapies—such as bone marrow transplant or gene therapy—requires more than medical eligibility. It involves understanding your options, preparing your body and mind, and ensuring you have the right support systems in place.
The Transformative Therapy Pre-Treatment Checklist is designed to help individuals with sickle cell disease and their care partners navigate the critical steps before starting curative-intent treatment. This resource supports informed decision-making, reduces uncertainty, and helps patients feel more confident as they move toward treatment.
What You Need to Know
Medical Preparation
☐ Complete pre-therapy labs (CBC, liver, kidney, viral panels, HLA typing)
☐ Confirm specialist consultations (hematology, cardiology, infectious disease, psychology)
☐ Update vaccinations and obtain dental clearance
☐ Discuss mental health readiness and support options
☐ Schedule baseline imaging or organ function tests (ECHO, MRI, etc.)
Preparation is Key to Success
What this checklist helps you prepare for:
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Understanding treatment pathways, risks, and expected outcomes
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Evaluating physical readiness, including baseline health and organ function
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Preparing emotionally and mentally for intensive treatment and recovery
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Planning for caregiving, housing, employment, and financial considerations
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Identifying questions to ask your care team before treatment begins
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Aligning expectations for life during and after a curative therapy
This checklist goes beyond clinical requirements to address the real-world considerations that shape treatment readiness and long-term success.
Whether you are exploring your options or actively preparing for treatment, this checklist is a practical tool to help you take the next step with clarity, confidence, and support.
